Reactome is a free, online, open-source, curated resource of core pathways and reactions in human biology.
Information is authored by expert biological researchers, maintained by the Reactome editorial staff and
cross-referenced to the NCBI Entrez Gene, Ensembl and
UniProt databases, the UCSC and
HapMap Genome Browsers, the KEGG
Compound and
ChEBI small molecule databases, PubMed, and
GO.
The curated human data are used to infer orthologous events
in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli.
Tools for data analysis include Skypainter and Biomart.
A description of Reactome has been published in
Genome Biology and Nucleic Acids Research.
Protein-protein interaction datasets, statistics and the editorial calendar are available.
The Reactome team thanks users for their comments on the pathway visualization tool.
Click on contact to reach us, on editorial to contribute to Reactome content,
and on subscribe to receive Reactome announcements.
Please take note of our disclaimer.
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- June 24, 2009 Version 29 Released
Version 29 includes the new topic, Axon guidance, covering NCAM signaling in neurite outgrowth.
Pathway topics updated with new curated events in this release include: Synaptic transmission (Glutamate Binding,
Activation of AMPA Receptors, and Synaptic Plasticity), DNA Repair (regulation of FANCD2 and FANCI activity in the Fanconi Anemia pathway),
and pathways related to diabetes (Regulation of insulin secretion and Unfolded protein response). With the annotation of receptors
for eicosanoids, leukotrienes, nucleotide-like (purinergic) molecules, LPA and lysosphingolipids, opsins, secretins, and GABA and related
molecules (class C/3 receptors), our annotation of interactions between G-coupled protein receptors (GPCRs) and their ligands is
essentially complete. The Telomere Maintenance pathway has been revised in this release.
T Huang,
PF Maness,
L Vosshall,
and
E Ziff
are our external reviewers in this release.
- March 31, 2009 Version 28 Released
New topics in Version 28 include signaling by PDGF,
striated Muscle Contraction,
and chaperonin-mediated protein folding and post-chaperonin tubulin folding.
(grouped with translation and post-translational protein modification into a new "Metabolism of protein" super-pathway).
Pathways updated with new curated events include GPCR signaling,
(olfactory signaling, amine and hormone ligand-binding receptor events and additional peptide ligand-binding receptor events), synaptic transmission
(Electrical transmission across Gap Junctions), hemostasis and signaling in the immune system (Tie2 signaling events and Basigin interactions. New metabolism topics include the peroxisomal metabolism of lipidsand glyoxylate
and Integration of energy metabolism (Glucose Regulation of Insulin Secretion).
N Cowan,
CH Heldin,
M Rush and
L Vosshall
are our external reviewers in this release.
- March 17, 2009 Version 1 of FlyReactome Released
The first official version of FlyReactome has been released and is accessible at http://fly.reactome.org ....
- More...
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