Reactome: Matthews, L

Details

Author of summation(s)
Surname	Matthews
First name	Lisa
Initials	L
Affiliation	Cold Spring Harbor Laboratory
The kinetochore is composed of a number of large protein ne... Cdh1 is degraded by the APC/C during in G1 and G0. This aut... DNA fragmentation in response to apoptotic signals is achie... Farnesyltransferase/geranyl-geranyltransferase catalyzes th... A combination of proteomic and bioinformatics analyses of TR... A current model of the arrangement of subunits within the T... A description of the mitotic proteins targeted by the mitoti... A regulated balance between cell survival and apoptosis is e... A study using cultured cells demonstrated connexon oligomeri... Acinus induces apoptotic chromatin condensation after cleava... Activated caspases cleave nuclear lamins causing the irreve... Activation of PAK-2p34 coincides with autophosphorylation of... Activation of the mitotic cyclin:Cdc2 complexes at mitosis r... Activation of the mitotic cyclin:Cdc2 complexes at mitosis r... Active caspase 8 associates with the membranes during apopto... Active caspase-3 is translocated from the cytoplasm to the n... Active Cyclin A:Cdk2 complexes phosphorylate and inactivate ... Adenoviral expression of the BAP31 cleavage product, p20 cau... Afadin serves as a linker of the actin cytoskeleton to the p... After forming in the cytoplasm, the Cyclin A:Cdk2 complexes ... After Pol II pauses by back tracking 2 -4 nuleotides on the ... After the initiation of DNA condensation during mitosis, Nu... Alpha and beta tubulin folding intermediates are formed thro... APC is phosphorylated on the 20 aa repeats by CK1 and potent... APC/C:Cdc20 is first activated at the prometaphase/metaphase... APOBEC3G is incorporated into virus particles through its as... APOBEC3G is multi-ubiquitinated by the Vif-Cul5-SCF complex. Apoptosis induced caspases cleave cortical actin network com... Apoptosis-induced cleavage of beta-catenin by caspase 3 res... Apoptotic cell death is achieved by the caspase-mediated cl... Apoptotic cells show dramatic rearrangements of tight junct... As cells enter S phase, HsCdc6p is phosphorylated by CDK pro... Assembly of the RAD50-MRE11-NBS1 complex at DNA double-stran... At the G1/S transition, the Cdh1 subunit of the APC:Cdh1 com... At the onset of mitosis, Cdh1 is phosphorylated by Cyclin B-... At the onset of mitosis, cyclin B is phosphorylated in the C... At the onset of mitosis, Cyclin B1 is phosphorylated in the ... ATM phosphorylates COP1 on Ser387 in response to DNA damage ... ATM phosphorylation promotes autoubiquitination of COP1 in v... ATM-dependent phosphorylation of COP1 on Ser(387) results in... ATR and ATM dependent phosphorylation of FANCD2 promotes th... Autoubiquitinated COP1 is degraded by the proteasome. The nu... B-TrCP associates with phosphorylated beta-catenin through t... B23 may function as a shuttle for the import of HIV Rev from... Base excision repair is initiated by DNA glycosylases that ... Base excision repair is initiated by a DNA glycosylase which... Base-free sugar-phosphate removal via the single-nucleotide ... Bcl-2 interacts with tBid, BIM, PUMA, NOXA, BAD Beta tubulin within the active (Factor E:alpha tubulin: Fact... Beta-catenin associates with the destruction complex through... Beta-catenin is then phosphorylated at Ser33. Phosphorylated... Beta-catenin is ubiquitinated by the SCF-B-TrCP1 complex. Beta-tubulin folding intermediates generated via ATP-depende... BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate wit... Both p53-independent and p53-dependent mechanisms of inducti... BP180 interacts with Plectin following the association of Pl... BP230 interacts with cytokeratins K5/K14 (Fontao et al., 2... BRCA2 plays a critical role in the initiation of DNA repair ... c-IAP1 is cleaved by caspase-3 producing a proapoptotic C-te... c-src has been shown to interact with Cx43 (Giepmans et al.,... c-Src phosphorylates Cx43 on Tyr 265. Cadherins are the major cell adhesion molecules at adherens ... Caspase mediated cleavage of desmoglein 1 leads to decreased... Caspase mediated cleavage produces a constitutively active k... Caspase-3 cleaves DFF45 between residues 224,225. Caspase-3 cleaves Tau at position 421 in vitro producing an ... Caspase-3 cleaves the DFF45 subunit of the DFF45:DFF40 compl... Caspase-3-mediated cleavage of ROCK I induces MLC phosphoryl... Caspase-8 mediated cleavage of BAP31 at the ER produces a ... Caspase-mediated cleavage of a number of proteins in the co... Caspase-mediated cleavage of Mst3 activates its intrinsic ki... Caspases initiate the destruction of the nucleus cleavage of... Caspases initiate the destruction of the nucleus cleavage of... Caspases-3 and -7 are directly cleaved downstream of caspase... CCT/TRiC facilitates folding of newly translated SK1 into it... CD151 interacts with the extracellular domain of the integr... CD4 is ubiquitinated in the CD4:Vpuâ€“h-Î²TrCP:Skp1 complex. Cdc25A dephosphorylates Cdk2 and activates cyclin E-Cdk2 and... cdc25A protein is degraded by the ubiquitin-proteasome machi... Cdc25A, and probably Cdc25B, regulate the entry into S phase... Cdc25B shuttles between the nucleus and the cytoplasm. Trans... Cdc25C is negatively regulated by phosphorylation on Ser 21... Cdh1 is multiubiquitinated by the APC/C:Cdh1 complex prior t... Cdk mediated phosphorylation of Emi1 is believed to promotes... CDK11p58 is a kinase that is active during mitosis when it a... Cell cycle progression is regulated by cyclin-dependent prot... Cell cycle proteins mulitubiquitinated by the APC/C are targ... Cell–extracellular matrix (ECM) interactions play a critical... Chk1 directly phosphorylates Cdc25A at Ser-123. Chk1 phospho... CK1a binds to Axin and phosphorylates beta-catenin at Ser45 ... Claspin is cleaved by caspase-7 during the initiation of apo... Claudin-1 takes part in homophilic interactions at tight ju... Claudins are the major cell adhesion molecules in tight junc... Cleavage of APC by caspase 3 and release of the amino-term... Cleavage of desmosomal proteins including desmoplakin contri... Cleavage of Etk by caspase-3 stimulates its kinase activity.... Cleavage of Gas2 during apoptosis is associated with changes... Cleavage of PKCtheta by Caspase-3 induces nuclear fragmenta... Cleavage of the C-terminal cytoplasmic domain of occludin d... Cleaved Satb1 dissociates from chromatin and may function i... Connexin-interacting proteins appear to function in regulati... Connexins (Cxs) are encoded by a large gene family predicted... Connexins follow the classical secretory transport route fro... Connexon-containing transport vesicles have been shown to em... Connexons may also traffic using a microtubule-independent m... COP1 is one of several E3 ubiquitin ligases responsible for... CRM1 associates directly with Rev through the Rev nuclear e... Crm1 is a nucleocytoplasmic transport factor that is believe... Cx proteins are cotranslationally inserted into ER membranes... Cx26 has also been reported to insert post-translationally i... Cyclin A is believed to be recognized by the APC/C:Cdc20 com... Cyclin A is synthesized and associates with Cdc2 in G1. Cycl... Cyclin A, functions in mitosis as well as DNA replication a... Cyclin A-Cdk2 prevents unscheduled APC reactivation during S... Cyclin A:Cdc2 complexes are detected in the nucleus earlier ... Cyclin A:Cdc2 complexes translocate to the nucleus in G1 and... Cyclin A:Cdk2 plays a key role in S phase entry by phosphory... Cyclin B is believed to be recognized by the APC/C:Cdc20 com... Cyclin D is targeted for degradation by multi-ubiquitination... Cyclin D turnover is regulated by ubiquitination and protea... Cyclin D:Cdk4 mediated phosphorylation of RB releases RB fro... Cyclin dependent kinases are themselves catalytically inacti... Cyclin E forms a complex with cdk2 and collaborates with the... Cytoplasmic cytochrome c binds to apoptotic protease activat... Dab2 is recruited to Cx43-based GJs possibly through a direc... Damaged purines are first cleaved by purine-specific glycosy... Damaged pyrimidines are first cleaved by pyrimide-specific g... Degradation of beta-catenin is initiated following amino-ter... Desmosomes represent one of the anchoring junctions mediatin... DFF associated with alpha-importin:beta-importin is transloc... Direct interactions between the histone H1 C-terminal domain... DNA Fragmentation Factor (DFF), is a heterodimer of 40 kDa (... DNA fragmentation in response to apoptotic signals is achiev... Docking of Cx43 at the plasma membrane may involve ZO-1 as ... Due to the crowded envirnoment within the cell, many protein... During G1 phase of the cell cycle, cyclin A is synthesized ... During G1, the activity of cyclin-dependent kinases (CDKs) i... During G1, the activity of cyclin-dependent kinases (CDKs) i... During G1, the activity of cyclin-dependent kinases (CDKs) i... During interphase, cyclin B1 shuttles continuously in and ou... During interphase, cyclin B1:Cdc2 shuttles continuously in a... During interphase, Nlp interacts with gamma-tubulin ring com... During interphase, phopshorylated Cdc25C is associated with ... During removal of DNA patch containing abasic residue, DNA g... During reverse transcription, APOBEC3G-mediated minus-strand... During the synthesis of actin and tubulin, the nascent ribos... E2F1 binds to E2F binding sites on the genome activating the... Emi1 destruction in early mitosis requires the SCFÎ²TrCP ubiq... Emi1 is also believed to be phosphorylated by Cyclin B:Cdc2 ... Emi1 promotes the accumulation of Cyclin A and entry into S ... Entry of a cell into anaphase requires the attachment of all... Entry of cofactor C to the factor E:alpha tubulin: factor D:... Epithelial cell-cell contacts consist of three major adhesio... Expression of the integrated HIV-1 provirus is dependent on ... Factor A:beta tubulin complex act as a reservoir capable of ... Factor E:alpha tubulin and Factor D:beta tubulin interact w... Failure to appropriately regulate cyclin E accumulation can ... FAK is a tyrosine kinase that localizes to focal adhesions a... FANCI is monoubiquitinated on lysine 523 in an FA core-com... FANCI phosphorylation may function as a molecular switch to ... Fanconi anemia (FA) is a genetic disease of genome instabili... Follow their formation, the Cyclin E:Cdk2 complexes are tran... Following caspase mediated cleavage, PAK-2p34 translocates t... Following caspase-3 cleavage, the fragments of DFF45 dissoci... Following CKI-mediated phosphorylation at Ser45, beta-cateni... Following cleavage of the damaged base, DNA glycosylase is d... Following connexon oligomerization, the hemichannels must be... Following iinduction of apoptosis in epithelial cells, tight... Following its association with SCF-Î²TrCP, phospho-Emi1 is po... Following its dephosphorylation in late mitosis, Cdh1 replac... Following its phosphorylation, Cdh1 dissociates from the APC... Following its release from DFF45, DFF40 forms homodimers, wh... Following its translocation to the nucleus, Cdc25 dephosphor... Following multi-ubiquitination by the Vif-Cul5-SCF complex, ... Following multiubiquitination, Cyclin A is targeted for dest... Following phosphorylation of the APC/C core subunits by mito... Following the association of BP180 with the forming hemidesm... Following the association of Rev with importin-beta, the Re... Following ubiquitination by the SCF(Skp2):Cks1 complex, phos... Following ubiquitination, securin is degraded by the 26S pro... Free, nuclear RanGTP is required for export processes out o... From late mitosis through G1 phase APC/C:Cdh1 insures the c... Full activity of most CDKs is dependent on CAK mediated phos... Full activity of most CDKs is dependent on CAK mediated phos... G1 phase- specific transcription will be described in a futu... G2-specific transcription will be described in a future rele... G2/M phase-specific transcription will be described in a fut... Gap junction plaque internalization and the disruption cell ... Gap junctions are intercellular communication channels forme... Gelsolin is cleaved by caspase-3 generating a constitutivel... GJ plaques, clusters of GJ channels, can be internalized to ... Group II chaperonins enclose substrate proteins following su... Hemi-channels appear to play a role in isosmotic cell volum... Hemi-channels consist of a single connexon and permit direc... Hemidesmosomes (HDs) are specialized multiprotein junctional... HIP-55 is an actin binding SH3 domain protein that is cleave... Homologous recombination repair of replication-independent d... Human mtDNA is transcribed by a dedicated mitochondrial RNA ... ILK interacts with the cytoplasmic domain of beta1-integrin ... In addition to its association with Cdh1 in G1 phase, Emi1 f... In addition to recruiting proteins and complexes necessary f... In apoptotic cells, intercellular contacts are disrupted th... In epithelial cells, desmosomes are anchoring junctions that... In G2 Cdk2, in association with cyclin A, phosphorylates E2F... In G2, the cyclin A:Cdk2 complex associates with E2F1 and E2... In late mitosis, Cdc20 dissociates from the APC/C and is rep... In one model of Vpr mediated induction of apoptosis, Vpr act... In order for Rev to function, multiple molecules must bind s... In order to facilitate the transport of incompletely spliced... In response to apoptotic signals, mitochondrial proteins ar... In response to stress signals, the p21-activated protein kin... In the absence of Tat, transcriptional elongation beyond pos... In the absence of the HIV-1 protein Tat, transcription of th... In the case of actin and tubulin folding, and perhaps other ... In the execution phase of apoptosis, effector caspases cleav... In the target cell, HIV-1-associated APOBEC3G binds to the H... In this complex Axin is bound to beta-catenin. In this form of the destruction complex, beta-catenin is no ... Inactive PAK-2 can be partially autophosphorylated in the re... Inactive PAK-2 is partially autophosphorylated at 5 serine s... Insertion of a connexon into the cell membrane results in th... Inside the nucleus, Ran-GTP associates with importin-beta. Interaction of Filamin with Migfiln mediates the association... Internalized GJ plaques are degraded by lysosomes. Lysosomal... Ionizing radiation results in an ATM-dependent movement of C... It has been observed, however, that the oligomerization of C... Junctional channels are an assembly of two docked connexons ... Like Cyclin A, NIMA-related kinase 2A (Nek2A) is degraded ... Lysine 561 of FANCD2 is monoubiquitinated by FANCL, a compon... MASK is cleaved in vitro by caspase 3 . C-terminally trunca... Microtubule nucleation at the centrosome is mediated by the ... Migfilin associates with actin filaments as a result of its ... Migfilin functions in cell shape modulation regulating filam... Migfilin interacts with VASP and regulates VASP localization... Mitotic activation of Plk1 is required for efficient displac... Monoubiquitinated FANCD2 and FANCI are targeted to chromati... Mulitubiquitinated Cyclin B is targeted for degradation by t... Multiubiquitinated Emi1 is degraded by the 26S proteasome. Murine PS-GAP interacts specifically with caspase-activated ... Myt1, which localizes preferentially to the endoplasmic reti... Necl-1 displays Ca2+-independent heterophilic cell-cell adhe... Necl-1 displays Ca2+-independent heterophilic cell-cell adhe... Necl-1 displays Ca2+-independent heterophilic cell-cell adhe... Necl-2 and Nectin 3 form a trans heterodimer. Necl-5 and Nectin 3 interact forming a trans heterodimer. Nectin-1 and Nectin 3 interact forming a trans heterodimer. Nectin-1 and Nectin-4 interact forming a trans heterodimer. Nectin-2 and Nectin-3 interact forming a trans heterodimer. Nectins and Nectin-like molecules (Necls) also undergo trans... Nectins are Ca(2+)-independent cell adhesion molecules which... Nectins are immunoglobulin-like cell adhesion molecules comp... Nek2A does not appear to be recruited to the APC/C by Cdc20 ... Nek2A is degraded by the 26S proteasome following ubiquityla... Nek2A is ubiquitinated by the APC/C-Cdc20 ubiquitin ligase. Nuclear export of the unspliced and partially spliced HIV-1 ... Nuclear import of Rev involves the cellular proteins includi... Nucleotide-independent transfer of beta-actin from prefoldin... NuMA can interact with microtubules by direct binding to tub... Oligomerization of connexins Cx32 and C26 has also been obse... Oligomerization of Cx43 may occur in the Trans-Golgi Network... Once in tight contact with the SCF (Skp2):Cks1 complex, phos... Once transported to the plasma membrane, junctional channels... One mechanism of transport of connexon-containing vesicles i... One model ( the direct inhibition model) describing the inhi... p21 associates with and inhibits Cyclin:Cdk complexes in the... p21 is transcriptionally activated by p53 after DNA damage. p21-activated protein kinase (PAK-2), also known as gamma-P... p27 translocates to the nucleoplasm where it associates with... PAK-2p34 is ubiquitinated prior to degradation (Jakobi et al... PAR-3 exists in a ternary complex with aPKC and PAR-6 to for... PARVB interacts with the actin cross-linking protein Alpha-a... Phospho-(Ser45, Thr41) beta-catenin is phosphorylated by GSK... Phosphorylated Cyclin D1 is degraded during S phase by the 2... Phosphorylation by mitotic kinases is believed to alter the ... Phosphorylation of APC subunits is required for Cdc20 mediat... Phosphorylation of CDK4 on Thr172 depends on prior D-type cy... Phosphorylation of cyclin D1 on Thr-286 by glycogen synthase... Phosphorylation of cyclin-dependent kinases (CDKs) by the CD... Phosphorylation of NlP by Plk1 regulates the interaction of ... Phosphorylation of the APC/C is believed to be required for ... Phosphorylation of the RD subunit of NEFL by P-TEFb(Cyclin T... Phosphorylation of the Spt5 subunit of DSIF by P-TEFb(Cyclin... Plectin is a major cross-linking protein of the three main ... Plk1 is associated with the centrosomes early in mitosis (Go... pRB contains, in its C terminus, a cyclin-cdk interaction mo... Prior to mitogen activation, the inhibitory proteins, INK4 (... Procaspase-3 and 7 are cleaved by the apoptosome. Protein metabolism comprises the pathways of translation, po... Proteolytic cleavage of the COOH-terminal domain of Mst3 b... Proteolytically activated PAK-2p34, but not full-length PAK-... PS-GAP (RGH10) interacts specifically with caspase-activated... Quasi-native alpha-tubulin folding intermediates generated v... RanGTP binds to a preformed Rev-CRM1 complex. Rape et al. have recently demonstrated that the order in whi... Recognition of p27 by SCF(Skp2) and the subsequent ubiquitin... Representatives of the apolipoprotein B mRNA editing enzyme ... Resolution of AP sites can occur through the single-nucleoti... RNA Pol II arrest is believed to be a result of irreversible... RPA is displaced from single stranded DNA. S phase-specific transcription will be described in a future... Securin is thought to be recognized by the APC/C:Cdc20 compl... Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 200... Skp2 is degraded by the anaphase promoting complex/Cyclosome... SMAC binds to the XIAP:caspase complexes. Smac/DIABLO regulates IAP function. Residues 56–59 of Smac/D... Src is believed to suppress gap junction communication by p... Stimulation of cell death by PAK-2 requires the generation ... Studies of human LSP have revealed that a minimal DNA fragme... Studies using microsomes have revealed that oligomerization ... Tat associates with the Cyclin T1 subunit of P-TEFb (Cyclin ... Tat associates with the Cyclin T1 subunit of the cellular ki... Termination of HIV-1 transcription is believed to be mechani... The cleavage of E-cadherin at both the intracellular and ex... The HIV-1 genome contains 9 genes encoded by a single trans... The 39-kDa mitochondrial transcription termination factor (m... The accessory protein, Cks1 promotes efficient interaction b... The actin-binding domain of plectin interacts with the first... The activity of the APC/C must be appropriately regulated du... The adherens junctions (AJ) are multiprotein complexes that ... The Anaphase Promoting Complex or Cyclosome (APC/C) function... The APC/C is activated by either Cdc20 or Cdh1. While both a... The APC/C:Cdh1 complex recognizes substrates containing a D... The assembly of gap junctions of involves (1) synthesis of c... The association between Tat, TAR and P-TEFb is believed to b... The association of PARVA with TESK1 appears to suppress ce... The association of Cks1 with both Skp2 and phosphorylated p2... The association of importin-beta with Ran-GTP causes the dis... The association of Rev with importin-beta is mediated by th... The beta-catenin destruction complex plays a key role in the... The caspase 3-mediated proteolytic processing of full-length... The CDK activity of the Cyclin A:Cdk2 complex is inhibited b... The centrosomal protein C-Nap1 is thought to play an importa... The centrosome is the primary microtubule organizing center ... The closure of Cx43 gap junction channels is observed follo... The cortical actin cytoskeletal network is lost during apopt... The CRB3–Pals1–PATJ complex is the second major cell polarit... The cytoplasmic tails of classical cadherins form a multipro... The degradation of cyclin B1, which appears to occur at the ... The details of the mechanism of POLRMT chain elongation have... The DFF40 cleaves DNA substrates to generate fragments posse... The E2F family of transcription factors regulate the transi... The elongation of HIV-1 mRNA depends upon the interaction of... The eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) pla... The exact composition of the destruction complex is not know... The FA pathway is negatively regulated through the USP1/UAF1... The factor B:alpha tubulin complex act as a reservoir capabl... The Fanconi anemia DNA repair pathway is negatively regulate... The focal adhesion protein alpha-parvin, interacts with paxi... The formation of centromeric chromatin assembly outside the ... The G1/S transition is facilitated by Cyclin E:Cdk2-mediated... The gap junction protein Cx43 interacts with the second PDZ ... The global pandemic of Human Immunodeficiency Virus (HIV) in... The GTPase dynamin, which functions in the completion of ves... The half-life of Cx is very short (1 to 5h) compared to othe... The highly conserved Wnt signaling proteins play critical ro... The HIV-1 accessory protein Vif (Viral infectivity factor) i... The HIV-1 Vif protein associates with the DNA editing enzyme... The HIV-1 Vpu protein promotes the degradation of the CD4 re... The human kinetochore, is a complex proteinaceous structure ... The human Wee1 kinase phosphorylates Cdc2 on tyrosine 15 in... The interaction between CCT and unfolded target proteins is ... The interaction between the Skp2 subunit of the SCF(Skp2) co... The interaction between Vif and the E3 ubiquitin ligase comp... The interactions among ILK, PINCH, and parvins are necess... The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004)... The life cycle of HIV-1 is divided into early and late phase... The localization of the Cdc25A, B and C proteins is dynamic ... The major HMG-box-containing chromatin proteins HMGB1 and HM... The mechanism by which human NuMA is translocated to the cen... The mechanism of connexin assembly into connexons has been w... The metaphase to anaphase transition during mitosis is trigg... The mitotic spindle becomes established once centrosomes hav... The Myc/Max heterodimer binds to elements in the cdc25A gene... The Nectin family of Ca2+-independent cell adhesion molecul... The nectin-like (Necl) family comprises five members, called... The NuMA protein, which functions as a nuclear matrix protei... The phosphorylation of Emi1 by Plk1 is believed to be involv... The phosphorylation of Emi1, which is required for its degra... The phosphorylation of the 20 aa repeats in APC results in a... The PINCH-ILK-parvin complex (Tu et al., 2001; Zhang et al.... The PINCH–ILK–Parvin complexes function in transducing div... The pRB C-terminus contains a cluster of seven candidate in ... The presynaptic phase of homologous DNA pairing and strand e... The processing of DNA double strand breaks requires resectio... The rapid translocation of cyclin B1:Cdc2 from the cytoplasm... The Ras suppressor, Rsu-1, interacts with the LIM 5 domain... The Rev-importin Î²-B23 complex is recruited to the nuclear p... The Rho GTPases, Cdc42 and Rac1, play critical roles in cell... The separation of sister chromatids in anaphase requires the... The SKP1 component of the SCF complex is recruited to the Vp... The subcellular localization of PAK-2 is controlled by nucle... The Tat protein is a viral transactivator protein that regul... The translocation of the DFF complex from the cytoplasm to t... The two B-type cyclins localize to different regions within ... Thirteen of the ~80 different proteins present in the respir... This event was inferred from the corresponding human Poll II... This event was inferred from the corresponding Reactome huma... This HIV-1 event was inferred from the corresponding human R... This HIV-1 event was inferred from the corresponding human R... This HIV-1 event was inferred from the corresponding human R... This HIV-1 event was inferred from the corresponding human R... This HIV-1 event was inferred from the corresponding human R... This HIV-1 event was inferred from the corresponding human R... Through videomicroscopy, a saltatory transport of connexon v... Tight junctions (TJs) are the most apical component of the e... Transcription of the heavy (H)-strand of mitochondrial DNA (... Transport of connexins along the secretory pathway (includin... Transport of connexins along the secretory pathway (includin... TRiC has broad recognition specificities, but in the cell it... TriC/CCT forms a binary complex with unfolded alpha- or beta... TriC/CCT-mediated beta-actin folding involves rapid ATP-inde... Ubiquitinated beta-catenin is degraded by the proteasome. Ubiquitinated CD4 is then subject to proteasome-mediated deg... Unfolded actins and tubulins bound to prefoldin are transfer... Unfolded actins and tubulins compete efficiently for binding... Until now, two kinds of annular gap junctions have been desc... Upon translocation to the cytoplasm, RanBP1 associates with... Vimentin is cleaved by several caspases during apoptosis (M... Vimentin is cleaved by several caspases during apoptosis (M... Vimentin is cleaved by several caspases during apoptosis (M... Vpr appears to function in anchoring the PIC to the nuclear... Vpr has been implicated in multiple processes during HIV-1 r... Vpr interacts with importin-alpha through alphaH1 and alphaH... Vpr interacts with the PTPC component ANT1. This interaction... Vpr translocates to the mitochondria. Vpu is expressed in the ER and associates with a membrane-pr... Vpu links beta-TrCP to CD4 at the ER membrane through intera... Wee1 phosphorylates Cdk2, inhibiting entry into S-phase (Wa... Wee1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 on ty... When in association with PS-GAP, PAK-2p34 is translocated to...
Author of entries
KIFC3 [cytosol] U K E G B C d O R H U R P 'APC/C:Cdh1-mediated degradation of Skp2' negatively regulates 'Association of Cks1 with SCF(Skp2) complex' 'Association of HMGB1/HMGB2 with chromatin' positively regulates 'Cleavage of DNA by DFF40' 'Association of Vif with APOBEC3G' negatively regulates 'Association of APOBEC3G with Gag' 'CDK11p58 [cytosol]' positively regulates 'Recruitment of Plk1 to centrosomes' 'Cdk4/6:INK4A complex [cytosol]' negatively regulates 'Formation of Cyclin D:Cdk4/6 complexes ' 'Crm1 [nucleoplasm]' positively regulates 'Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm' 'DP-1:E2F1 complex [nucleoplasm]' positively regulates 'Activation of E2F target genes at G1/S' 'FANCD2 [nucleoplasm]' is required for 'Monoubiquitination of FANCI by the FA ubiquitin ligase complex' 'FANCI [nucleoplasm]' is required for 'Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex' 'FANCJ/BRIP1 [nucleoplasm]' negatively regulates 'Strand exchange/Branch migration' 'Interaction of Vpr with importin alpha' positively regulates 'Import of PIC to the Host Nucleus' 'Myc/Max heterodimer [nucleoplasm]' positively regulates 'Activation of Cdc25A by c-myc' 'p53 ser-15 phosphorylated [nucleoplasm]' positively regulates 'Transcritional activation of p21 by p53 after DNA damage' 'RanBP1 [nuclear membrane]' positively regulates 'Hydrolysis of Ran:GTP to Ran:GDP' 'RanGap1 [nuclear membrane]' positively regulates 'Hydrolysis of Ran:GTP to Ran:GDP' 'Vpr binds nucleoporins' positively regulates 'Import of PIC to the Host Nucleus' (APC/C:Cdh1)-targeted cell cycle proteins [cytosol] /figures/Cdc20.targets.jpg /figures/Cdh1.targets.jpg /figures/Fig0.gif /figures/Fig5.gif /figures/Fig7.jpg /figures/gapjunc_Fig1.jpg /figures/gapjunc_Fig2.jpg /figures/gapjunc_Fig3.jpg /figures/gapjunc_Fig3bis.jpg /figures/gapjunc_Fig4.jpg /figures/HIV1_LifeCycle.jpg /figures/HIV1_transcription_reg.jpg /figures/mito3.gif /figures/newG2M.jpg /figures/Regulation_APC_activators.jpg /figures/RNA_transport.jpg /figures/SCF_Skp2_degradation.jpg /figures/securin.jpg /figures/Skp2_degradation.jpg /figures/TAT_mediated_Elong.jpg /figures/tightjunctions.jpg /figures/Tub1.png /figures/Tub10.png /figures/Tub3.png /figures/Tub4.png /figures/Tub5.png /figures/Tub6.png /figures/Tub7.png /figures/Tub7a.png /figures/Tub8.png /figures/Tub9.png /figures/vif1.jpg /figures/vif2.jpg /figures/Vpu.jpg 14-3-3 protein gamma [cytosol] U K E G B C d O R H U R P 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing [Homo sapiens, Human immunodeficiency virus 1] 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing [Homo sapiens, Human immunodeficiency virus 1] 26S protease regulatory subunit 4 [nucleoplasm] U K E G B C d O R H U R 26S protease regulatory subunit 6A [nucleoplasm] U K E G B C d O R H U R 26S protease regulatory subunit 6B [nucleoplasm] U K E G G B B C C d d O R H U R 26S protease regulatory subunit 7 [nucleoplasm] U K E G B C d O R H U R 26S protease regulatory subunit S10B [nucleoplasm] U K E G B C d O R H U R 26S proteasome [nucleoplasm] 26S proteasome non-ATPase regulatory subunit 1 [nucleoplasm] U K E G B C d R H U R 26S proteasome non-ATPase regulatory subunit 10 [nucleoplasm] U K E G B C d O R H U R P P P 26S proteasome non-ATPase regulatory subunit 11 [nucleoplasm] U K E G B C d O R H U R 26S proteasome non-ATPase regulatory subunit 12 [nucleoplasm] U K E G B C d O R H U R 26S proteasome non-ATPase regulatory subunit 13 [nucleoplasm] U K E G B C d O R H U R 26S proteasome non-ATPase regulatory subunit 2 [nucleoplasm] U K E G B C d O R H U R 26S proteasome non-ATPase regulatory subunit 3 [nucleoplasm] U K E G B C d R H U R 26S proteasome non-ATPase regulatory subunit 4 [nucleoplasm] U K E G B C d O R H U R P P P P P P 26S proteasome non-ATPase regulatory subunit 5 [nucleoplasm] U K E G B C d O R H U R 26S proteasome non-ATPase regulatory subunit 6 [nucleoplasm] U K E G B C d R H U R 26S proteasome non-ATPase regulatory subunit 7 [nucleoplasm] U K E G B C d O R H U R 26S proteasome non-ATPase regulatory subunit 8 [nucleoplasm] U K E G B C d R H U R 26S proteasome non-ATPase regulatory subunit 9 [nucleoplasm] U K E G B C d O R H U R 26S proteasome-associated pad1 homolog [nucleoplasm] U K E G B C d O R H U R 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest [Homo sapiens, Human immunodeficiency virus 1] 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest [Homo sapiens, Human immunodeficiency virus 1] Aborted HIV-1 early elongation complex [nucleoplasm] Abortive termination of HIV-1 elongation after arrest [Homo sapiens, Human immunodeficiency virus 1] Abortive elongation of HIV-1 transcript in the absence of Tat [Homo sapiens, Human immunodeficiency virus 1] Abortive HIV-1 initiation after formation of the first phosphodiester bond [Homo sapiens, Human immunodeficiency virus 1] Abortive HIV-1 Initiation After Second Transition [Homo sapiens, Human immunodeficiency virus 1] Abortive HIV-1 Initiation Before Second Transition [Homo sapiens, Human immunodeficiency virus 1] Abortive termination of HIV-1 early transcription elongation by DSIF:NELF [Homo sapiens, Human immunodeficiency virus 1] Abortive termination of HIV-1 elongation after arrest [Homo sapiens, Human immunodeficiency virus 1] Acinus [cytosol] U K E G B C d O R H U R Acinus fragment (1-1093) [cytosol] U K E G B C d O R H U R Acinus fragment (1094-1341) [cytosol] U K E G B C d O R H U R Actin [cytosol] U K E G G G G B B B B C C C C d d d d actin [cytosol] actin [peroxisomal membrane] actin [plasma membrane] actin/tubulin-bound CCT/TriC [cytosol] actin/tubulin-bound CCT/TriC(ADP) [cytosol] Actin/tubulin:prefoldin complex associates with CCT/TriC [Bos taurus, Oryctolagus cuniculus] Actin/tubulin:prefoldin complex associates with CCT/TriC [Homo sapiens] actin:ATP [cytosol] actin:ATP [cytosol] Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [Homo sapiens] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 [Homo sapiens] Activation of Cdc25A by c-myc [Homo sapiens] Activation of DNA fragmentation factor [Homo sapiens] Activation of E2F target genes at G1/S [Homo sapiens] Activation of GT [Homo sapiens, Human immunodeficiency virus 1] active caspase 3 [plasma membrane] active caspase-3 [nucleoplasm] active caspase-6 [cytosol] active caspase-6 [nucleoplasm] active caspase-7 [nucleoplasm] active nuclear Cyclin B1:Cdc2 complexes [nucleoplasm] Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition [Homo sapiens, Human immunodeficiency virus 1] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript [Homo sapiens, Human immunodeficiency virus 1] Addition of nucleotides between position +11 and +30 on HIV-1 transcript [Homo sapiens, Human immunodeficiency virus 1] Addition of nucleotides leads to HIV-1 transcript elongation [Homo sapiens, Human immunodeficiency virus 1] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition [Homo sapiens, Human immunodeficiency virus 1] Addition of the third nucleotide on the nascent HIV-1 transcript [Homo sapiens, Human immunodeficiency virus 1] Adducin alpha [cytosol] U K E G B C d O R R H H U R R Adherens junctions interactions [Homo sapiens] ADP [endoplasmic reticulum membrane] C C P ADP [plasma membrane] C C P ADP is exchanged for ATP in the ADP:CCT/TriC:tubulin complex [Mus musculus, Oryctolagus cuniculus] ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex [Homo sapiens] Afadin [cytosol] U E O U P P P Afadin [cytosol] U K E G B C d R H R Afadin:F-actin [cytosol] Afadin:F-actin [cytosol] ALMS1 [cytosol] U K E G B C d O O R H U R Alpha adducin fragment (1-633) [cytosol] U K E G B C d O R R H H U R R Alpha adducin fragment (634-737) [cytosol] U K E G B C d O R R H H U R R alpha catenin [cytosol] U K E G B C d O R H U R P P alpha centractin [cytosol] U K E G B C d O R H U R alpha K tubulin -1 [cytosol] U K E G B C d O R H U R alpha K tubulin -1 folding intermediate [cytosol] U K E G B C d O R H U R alpha tubulin -1 [cytosol] U K E G B C d O R H U R alpha tubulin -1 folding intermediate [cytosol] U K E G B C d O R H U R alpha tubulin 2.1 [cytosol] U K K E E G G G B B B C C C d d d O R R H H U R R alpha tubulin 2.1 folding intermediate [cytosol] U K K E E G G G B B B C C C d d d O R R H H U R R alpha tubulin 2.2 [cytosol] U K K E E G G G B B B C C C d d d O R R H H U R R alpha tubulin 2.2 folding intermediate [cytosol] U K K E E G G G B B B C C C d d d O R R H H U R R alpha tubulin 3 [cytosol] U K E G B C d O R H U R alpha tubulin 3 folding intermediate [cytosol] U K E G B C d O R H U R alpha tubulin 6 [cytosol] U K E G B C d R H U R alpha tubulin 6 folding intermediate [cytosol] U K E G B C d R H U R alpha tubulin [cytosol] alpha tubulin folding intermediate [cytosol] alpha tubulin:GTP [cytosol] alpha-beta heterodimer [cytosol] alpha-beta heterodimer [cytosol] alpha-beta tubulin dimer [cytosol] alpha-catenin [plasma membrane] U K E G B C d O R H U R P P alpha-tubulin [cytosol] alpha-tubulin folding intermediate [cytosol] alpha-tubulin folding intermediate [cytosol] alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B [Homo sapiens] alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B [Bos taurus] alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E [Bos taurus] alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E [Homo sapiens] alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B [Homo sapiens] alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B [Bos taurus] alpha/beta parvin [cytosol] alpha/beta tubulin folding intermediate [cytosol] alpha/beta-tubulin folding intermediates [cytosol] anaphase promoting complex (APC/C) [nucleoplasm] ANT1:Vpr complex [mitochondrial inner membrane] AP-2 clathrin coat assembly protein [peroxisomal membrane] U K E G B C d O R H U R P APC [cytosol] APC fragment (1-777) [cytosol] APC fragment (778-2843) [cytosol] APC-Cdc20 mediated degradation of Nek2A [Homo sapiens] APC/C-mediated degradation of cell cycle proteins [Homo sapiens] APC/C:Cdc20 mediated degradation of Cyclin B [Homo sapiens] APC/C:Cdc20 mediated degradation of mitotic proteins [Homo sapiens] APC/C:Cdc20 mediated degradation of Securin [Homo sapiens] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [Homo sapiens] APC/C:Cdh1-mediated degradation of Skp2 [Homo sapiens] Apc1/Tsg24 [cytosol] U K E G G B B C C d d R H U R Apc1/Tsg24 [nucleoplasm] U K E G G B B C C d d R H U R Apc10/Doc1 [cytosol] U K E G B C d R H U R P Apc10/Doc1 [nucleoplasm] U K E G B C d R H U R P Apc11 [cytosol] U K E G B C d R R R R R R H H H H H H U R R R R R R Apc11 [nucleoplasm] U K E G B C d R R R R R R H H H H H H U R R R R R R Apc2 [cytosol] U K E G G B B C C d d O R H U R Apc2 [nucleoplasm] U K E G G B B C C d d O R H U R Apc3/Cdc27 [cytosol] U K E G G G G B B B B C C C C d d d d O R H U R Apc3/Cdc27 [nucleoplasm] U K E G G G G B B B B C C C C d d d d O R H U R Apc4 [cytosol] U K E G B C d O R H U R Apc4 [nucleoplasm] U K E G B C d O R H U R Apc5 [cytosol] U E G B C d O R H U R Apc5 [nucleoplasm] U E G B C d O R H U R Apc6/Cdc16 [cytosol] U K E G B C d O R H U R R Apc6/Cdc16 [nucleoplasm] U K E G B C d O R H U R R Apc7 [cytosol] U E G B C d O R H U R Apc7 [nucleoplasm] U E G B C d O R H U R Apc8/Cdc23 [cytosol] U K E G B C d O R H U R Apc8/Cdc23 [nucleoplasm] U K E G B C d O R H U R APC_1 [cytosol] U K E G B C d O O O O R H U R P P P P P P P APC_1 fragment (1-777) [cytosol] U K E G B C d O O O O R H U R P P P P P P P APC_1 fragment (778-2843) [cytosol] U K E G B C d O O O O R H U R P P P P P P P APC_2 [cytosol] U K E G B C d O O O O R H U R P P P P P P P APC_2 fragment (1-777) [cytosol] U K E G B C d O O O O R H U R P P P P P P P APC_2 fragment (778-2843) [cytosol] U K E G B C d O O O O R H U R P P P P P P P APOBEC3G [cytosol] U K K E G B C d O O R H U R APOBEC3G [cytosol] U K K E G B C d O O R H U R APOBEC3G [cytosol] APOBEC3G mediated resistance to HIV-1 infection [Homo sapiens, Human immunodeficiency virus 1] APOBEC3G:HIV-1PIC [cytosol] APOBEC3G:RTC with deaminated minus sssDNA:tRNA primer:RNA template [cytosol] APOBEC3G:RTC with minus sssDNA:tRNA primer:RNA template [cytosol] APOBEC3G:Vif:Cul5:SCF complex [cytosol] Apoptotic cleavage of cell adhesion proteins [Homo sapiens] ARFGEF2 [cytosol] U K E G B C d O R H U R Assembly of gap junction plaques [Homo sapiens] Assembly of the destruction complex [Homo sapiens] Association of PARVA with TESK1 [Homo sapiens] Association of APOBEC3G with Gag [Homo sapiens, Human immunodeficiency virus 1] Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand [Homo sapiens, Human immunodeficiency virus 1] Association of APOBEC3G:Vif with the Cul5-SCF complex [Homo sapiens, Human immunodeficiency virus 1] Association of beta-catenin with the SCF-beta-TrCP1 ubiquitin ligase complex [Homo sapiens] Association of beta-catenin with the destruction complex [Homo sapiens] Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) [Mus musculus, Oryctolagus cuniculus] Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) [Homo sapiens] Association of CCT/TriC with sphingosine kinase 1 [Homo sapiens] Association of Cdh1 with the APC/C [Homo sapiens] Association of cell cycle proteins with the APC/C:Cdh1 complex [Homo sapiens] Association of Cks1 with SCF(Skp2) complex [Homo sapiens] Association of Cx43 with ZO-1 [Homo sapiens] Association of Cx43 with ZO-1 [Rattus norvegicus] Association of Cyclin A with the APC/C [Homo sapiens] Association of Cyclin A:Cdk2 with Cdh1 [Homo sapiens] Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 [Homo sapiens] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex [Homo sapiens] Association of DFF with alpha:beta importin [Homo sapiens] Association of DFF40 with chromatin [Homo sapiens] Association of DFF40 with DFF45 [Homo sapiens] Association of Emi1 with Cdc20 [Homo sapiens] Association of Emi1 with Cdh1 [Homo sapiens] Association of Golgi transport vesicles with microtubules [Homo sapiens] Association of HMGB1/HMGB2 with chromatin [Homo sapiens] Association of INK4A with Cdk4/6 [Homo sapiens] Association of mTERF with the termination sequence [Homo sapiens] Association of multimerized Rev with beta-importin [Homo sapiens, Human immunodeficiency virus 1] Association of Nek2A with MCC:APC/C [Homo sapiens] Association of NuMA with microtubules [Homo sapiens] Association of Pak2 with Cdc42-GTP [Oryctolagus cuniculus] Association of Ran-GTP with importin-beta [Homo sapiens, Human immunodeficiency virus 1] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex [Homo sapiens, Human immunodeficiency virus 1] Association of Rb with Cyclin E:Cdk2 complexes [Homo sapiens] Association of Securin with Cdc20:APC/C complex [Homo sapiens] Association of Tat with P-TEFb(Cyclin T1:Cdk9) [Homo sapiens, Human immunodeficiency virus 1] Association of TFAM:mt promoter complex with POLRMT:TFB2M [Homo sapiens] Association of TriC/CCT with target proteins during biosynthesis [Homo sapiens] Association of Vif with APOBEC3G [Homo sapiens, Human immunodeficiency virus 1] Association of Vpr with ANT1 [Homo sapiens, Human immunodeficiency virus 1] Association of Vpu with CD4 [Homo sapiens, Human immunodeficiency virus 1] ATM/ATR kinase Aurora A [cytosol] U K E G B C d O O R R R R R R R H H H H H H U R R R R R R P P P P P P P P P P D D D Aurora B [cytosol] U K E G B C d O R H U R Auto-phosphorylated PAK-2 (p27 regulatory fragment) [cytosol] U Autodegradation of Cdh1 by Cdh1:APC/C [Homo sapiens] Autodegradation of the E3 ubiquitin ligase COP1 [Homo sapiens] Autophosphorylation of PAK-2p34 [Oryctolagus cuniculus] Autophosphorylation of PAK-2p34 in the activation loop [Homo sapiens] Autoubiquitination of phospho-COP1(Ser-387 ) [Homo sapiens] Axin [cytosol] U K E G B C d O O O R H U R P P Axin:GSK3:CK1alpha:APC:PP2A complex [cytosol] BAP31 [endoplasmic reticulum membrane] U K E G B C d O O R H U R BAP31 fragment (165-237) [endoplasmic reticulum membrane] U K E G B C d O O R H U R BAP31 fragment (2-164) [endoplasmic reticulum membrane] U K E G B C d O O R H U R BAP31 fragment (238-246) [cytosol] U K E G B C d O O R H U R Bcl-2 interacting BH-3 only proteins [cytosol] Bcl-XL interacting BH3-only proteins [cytosol] Bcl-XL:BH3-only protein complex [mitochondrial outer membrane, cytosol] Bcl2:BH3-only protein complex [cytosol, mitochondrial outer membrane] beta 5 tubulin [cytosol] U K E G B C d R H R beta tubulin 1 [cytosol] U K E G B C d R H U R beta tubulin 1 folding intermediate [cytosol] U K E G B C d R H U R beta tubulin 2A [cytosol] U K E G B C d R H U R beta tubulin 2A folding intermediate [cytosol] U K E G B C d R H U R beta tubulin 2B [cytosol] U K E G B C d R H U R beta tubulin 2B folding intermediate [cytosol] U K E G B C d R H U R beta tubulin 2C [cytosol] U K E G B C d O R H U R beta tubulin 2C folding intermediate [cytosol] U K E G B C d O R H U R beta tubulin 4 [cytosol] U K E G B C d O O R H U R beta tubulin 4 folding intermediate [cytosol] U K E G B C d O O R H U R beta tubulin 4q [cytosol] U K E G B C d R H U R beta tubulin 4q folding intermediate [cytosol] U K E G B C d R H U R beta tubulin 5 [cytosol] U K E G B C d O R H U R beta tubulin 5 folding intermediate [cytosol] U K E G B C d O R H U R beta tubulin 6 [cytosol] U K E G B C d R H U R beta tubulin 6 folding intermediate [cytosol] U K E G B C d R H U R beta tubulin [cytosol] beta tubulin [cytosol] beta tubulin:GDP [cytosol] beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] beta-actin [cytosol] U K E G B C d O O R H U R beta-catenin [cytosol] beta-catenin [plasma membrane] Beta-catenin phosphorylation cascade [Homo sapiens] beta-catenin-1 [cytosol] U K E G B C d O O O R R R H H H U R R R P P P P P P P P P P beta-catenin-1 [plasma membrane] U K E G B C d O O O R R R H H H U R R R P P P P P P P P P P beta-catenin-1(1-115) [cytosol] U K E G B C d O O O R R R H H H U R R R P P P P P P P P P P beta-catenin-1(116-376) [cytosol] U K E G B C d O O O R R R H H H U R R R P P P P P P P P P P Beta-catenin/gamma catenin [plasma membrane] beta-catenin:Axin:GSK3:CK1alpha:APC:PP2A complex [cytosol] Beta-TrCP [cytosol] U K E G B C d O R H U R P beta-tubulin [cytosol] beta-tubulin folding intermediate [cytosol] beta-tubulin folding intermediate [cytosol] beta-tubulin folding intermediate [cytosol] Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A [Bos taurus] Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A [Homo sapiens] Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D [Bos taurus] Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D [Homo sapiens] Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A [Homo sapiens] Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A [Bos taurus] Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E [Bos taurus] Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E [Homo sapiens] beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C [Bos taurus] Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C [Homo sapiens] Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi [Homo sapiens] Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi [Bos taurus] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL [Homo sapiens] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 [Homo sapiens] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex [Homo sapiens] Borealin [cytosol] U K E G B C d O R H U R BP180 [plasma membrane] U K E G B C d O O R R H H U R BP180 interacts extracellularly with Laminin 332 [Homo sapiens] BP180 interacts intracellularly with plectin and integrin beta4 [Homo sapiens] BP230 interacts with keretin K5/K14 [Homo sapiens] BP230 is recruited to the hemidesmosome [Homo sapiens] BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] BRCA1:BRCA2:PALB2 [nucleoplasm] Breakdown of the nuclear lamina [Homo sapiens] BUB1 [cytosol] U K E G B C d O R H U R Budding of connexon-containing transport vesicles from the Golgi [Homo sapiens] C-IAP1(1-372) [cytosol] U K E G B C d O R H U R P C-IAP1(373-618 ) [cytosol] U K E G B C d O R H U R P c-src [cytosol] U K E G B C d O R R H H U R R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D c-Src [plasma membrane] U K E G B C d O R R H H U R R P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D c-src associated cx43 hemi-channel [plasma membrane] c-src associates with Cx43 in gap junctions [Homo sapiens] c-src mediated regulation of Cx43 function and closure of gap junctions [Homo sapiens] c-src-associated Cx43 junctional channel [plasma membrane] Cadherin trans-homodimer [cell junction] Cadherin-10 [plasma membrane] U K E G B C d O R H U R Cadherin-11 [plasma membrane] U K E G B C d O R H U R Cadherin-13 [plasma membrane] U K E G B C d O R H U R Cadherin-18 [plasma membrane] U E G B C d O R H U R Cadherin-24 [plasma membrane] U K E G B C d R H U R Cadherin-5 [plasma membrane] U K E G B C d O R H U R Cadherin-6 [plasma membrane] U K E G B C d O R H U R Cadherin-7 [plasma membrane] U K E G B C d O R R H H U R R Cadherin-8 [plasma membrane] U K E G B C d O R H U R Cadherin-9 [plasma membrane] U K E G B C d R H U R Cadherin:Catenin complex [plasma membrane] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes [Homo sapiens] CAK-mediated phosphorylation of Cyclin A:Cdk2 [Homo sapiens] CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes [Homo sapiens] CAK-mediated phosphorylation of Cyclin E:Cdk2 [Homo sapiens] Caldesmon [cytosol] U K E G B C d O R H U R capped HIV-1 pre-mRNA [nucleoplasm] Casein kinase alpha subunit [cytosol] U K E G B C d O R R R H H U R R R P P P P Casein kinase alpha' subunit [cytosol] U K E G B C d O R H U R Casein kinase I, delta [cytosol] U K E G B C d O O R H U R Casein kinase II [cytosol] Casein kinase II beta subunit [cytosol] U K E E E G B C d O R H U R P P P Caspase 3-mediated cleavage of DFF45 (117) [Homo sapiens] Caspase 3-mediated cleavage of PKC delta [Homo sapiens] caspase 3/caspase 7 [cytosol] Caspase cleaved DFF45 (117) [nucleoplasm] Caspase mediated cleavage of alpha-II-Fodrin [Homo sapiens] Caspase mediated cleavage of APC [Homo sapiens] Caspase mediated cleavage of BAP31 [Homo sapiens] Caspase mediated cleavage of beta-catenin [Homo sapiens] Caspase mediated cleavage of C-IAP1 [Homo sapiens] Caspase mediated cleavage of HIP-55 [Homo sapiens] Caspase mediated cleavage of vimentin at IDVD (259) [Homo sapiens] Caspase-3 (large subunit) [nucleoplasm] U K E G B C d O R R H H U R R P P P