Reactome: 26S protease regulatory subunit 4 [cytosol]

Details

Participates in processes
Name	26S protease regulatory subunit 4 P26s4
Stable identifier	REACT_5615.1
Links to corresponding entries in other databases	BioGPS Gene:5700 CTD Gene:5700 ENSEMBL:ENSG00000100764 Entrez Gene:5700 HapMap:NM_002802 KEGG Gene:5700 OMIM:602706 RefSeq:NM_002802 RefSeq:NP_002793 UCSC human:P62191 UniProt:P62191 dbSNP Gene:5700
Other identifiers related to this sequence	PRS4_HUMAN, P49014, Q03527, Q6IAW0, Q96AZ3, ENSG00000100764, ENST00000261303, ENSP00000261303, 688_at, 204219_s_at, L02426_at, 204219_3p_s_at, g4506206_3p_a_at, g4506206_3p_s_at, A_32_P57870, A_24_P647965, A_24_P84873, A_24_P347488, A_32_P9700, A_23_P151795, A_32_P57865, CCDS32139, GE603990, GE61348, GE855735, AK222668, BT009826, BC067741, L02426, CR457044, BC000512, BC016368, BC073818, EntrezGene:5700, GI_24430150-S, ILMN_38401, ILMN_43617, ILMN_3756, ILMN_40173, ILMN_43489, IPI00011126, IPI00848107, MIM:602706, BAD96388, AAP88828, AAH67741, AAA35484, CAG33325, AAH00512, AAH16368, AAH73818, NM_002802, XR_018030, XR_017485, XR_018684, XR_019491, XR_016204, XR_017630, XR_016986, XR_019627, XR_019339, XR_018613, XR_016133, NP_002793, Hs.576609, Hs.646779, Hs.646945, Hs.647519, Hs.647965, Q53HB3, Q53XL8, Q6NW36, P62191, Q53HB3_HUMAN, Q53XL8_HUMAN, Q6NW36_HUMAN, PRS4_HUMAN, IPR003960, IPR001957, IPR003959
Reference entity	UniProt:P62191 PSMC1
Cellular compartment	cytosol GO
Organism	Homo sapiens
Component of	26S proteasome [cytosol]
HIV Infection - Host Interactions of HIV factors - Vif-mediated degradation of APOBEC3G - Proteosome-mediated degradation of APOBEC3G [Homo sapiens] - Vpu mediated degradation of CD4 - Degradation of ubiquitinated CD4 [Homo sapiens] Cell Cycle Checkpoints - G1/S DNA Damage Checkpoints - p53-Dependent G1/S DNA damage checkpoint - p53-Dependent G1 DNA Damage Response - Stabilization of p53 - Autodegradation of the E3 ubiquitin ligase COP1 - Proteasome mediated degradation of COP1 [Homo sapiens] - p53-Independent G1/S DNA damage checkpoint - p53-Independent DNA Damage Response - Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - Proteolytic degradation of ubiquitinated-Cdc25A [Homo sapiens] DNA Replication - Mitotic M-M/G1 phases - M/G1 Transition - DNA Replication Pre-Initiation - Assembly of the pre-replicative complex - CDT1 association with the CDC6:ORC:origin complex - Ubiquitinated geminin is degraded by the proteasome [Homo sapiens] - Synthesis of DNA - Switching of origins to a post-replicative state - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] - Regulation of DNA replication - Removal of licensing factors from origins - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] Metabolism of amino acids and derivatives - Regulation of ornithine decarboxylase (ODC) - 26S proteosome degrades ODC holoenzyme complex [Homo sapiens] Regulation of activated PAK-2p34 by proteasome mediated degradation - Proteasome mediated degradation of PAK-2p34 [Homo sapiens] Signaling by Wnt - Degradation of beta-catenin by the destruction complex - Degradation of ubiquitinated -beta catenin by the proteasome [Homo sapiens] Apoptosis - Regulation of Apoptosis - Regulation of activated PAK-2p34 by proteasome mediated degradation - Proteasome mediated degradation of PAK-2p34 [Homo sapiens] Cell Cycle, Mitotic - S Phase - Synthesis of DNA - Switching of origins to a post-replicative state - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] - Ubiquitin-dependent degradation of Cyclin D - Ubiquitin-dependent degradation of Cyclin D1 - Proteasome mediated degradation of Cyclin D1 [Homo sapiens] - Regulation of DNA replication - Removal of licensing factors from origins - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] - Mitotic M-M/G1 phases - M/G1 Transition - DNA Replication Pre-Initiation - Assembly of the pre-replicative complex - CDT1 association with the CDC6:ORC:origin complex - Ubiquitinated geminin is degraded by the proteasome [Homo sapiens] - Regulation of mitotic cell cycle - APC/C-mediated degradation of cell cycle proteins - Regulation of APC/C activators between G1/S and early anaphase - SCF-beta-TrCP mediated degradation of Emi1 - SCF-mediated degradation of Emi1 [Homo sapiens] - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins - APC/C:Cdc20 mediated degradation of mitotic proteins - APC/C:Cdc20 mediated degradation of Securin - Degradation of multiubiquitinated Securin [Homo sapiens] - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - Degradation of multiubiquitinated cell cycle proteins [Homo sapiens] - APC/C:Cdh1-mediated degradation of Skp2 [Homo sapiens] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Degradation multiubiquitinated Cyclin A [Homo sapiens]
Other forms of this molecule	26S protease regulatory subunit 4 [nucleoplasm]
Entities deduced on the basis of this entity	ENSCAFP00000025789 [cytosol] E E [Canis familiaris] Q5E9D7 [cytosol] U K E E G B C d R H R [Bos taurus] Q9TS79 [cytosol] U E E [Bos taurus] A4FUZ3 [cytosol] U E [Bos taurus] B2VQ18 [cytosol] U E [Bos taurus] Homologues of 26S protease regulatory subunit 4 [cytosol] [Bos taurus] P62192 [cytosol] U K E E G B C d R H R [Mus musculus] P62193 [cytosol] U K E E G B C d R H R [Rattus norvegicus] B5FZJ4 [cytosol] U E [Taeniopygia guttata] B5FZJ3 [cytosol] U E [Taeniopygia guttata] ENSTGUP00000012812 [cytosol] E E [Taeniopygia guttata] Homologues of 26S protease regulatory subunit 4 [cytosol] [Taeniopygia guttata] ENSXETP00000034242 [cytosol] E E [Xenopus tropicalis] Q6IQ72 [cytosol] U K E E G G G B B B C C C d d d R H R [Danio rerio] Q7ZWD1 [cytosol] U K E E G G B B C C d d R H R [Danio rerio] A8KC30 [cytosol] U E [Danio rerio] Homologues of 26S protease regulatory subunit 4 [cytosol] [Danio rerio] P48601 [cytosol] U K E E G B C d F R [Drosophila melanogaster] O16368 [cytosol] U K E W E G B C d R H R [Caenorhabditis elegans] P46466 [cytosol] U K E [Oryza sativa] Q8W422 [cytosol] U K E [Oryza sativa] Homologues of 26S protease regulatory subunit 4 [cytosol] [Oryza sativa] Q55BV5 [cytosol] U E d [Dictyostelium discoideum] Q8IJW0 [cytosol] U K E P [Plasmodium falciparum]

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