Reactome: 26S protease regulatory subunit 6A [cytosol]

Details

Participates in processes
Name	26S protease regulatory subunit 6A TAT-binding protein 1 TBP-1 Proteasome subunit P50
Stable identifier	REACT_5909.1
Links to corresponding entries in other databases	BioGPS Gene:5702 CTD Gene:5702 ENSEMBL:ENSG00000165916 Entrez Gene:5702 HapMap:NM_002804 KEGG Gene:5702 OMIM:186852 RefSeq:NM_002804 RefSeq:NP_002795 UCSC human:P17980 UniProt:P17980 dbSNP Gene:5702
Other identifiers related to this sequence	PRS6A_HUMAN, B2R8V1, Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3, ENSG00000165916, ENST00000298852, ENSP00000298852, 592_at, 201267_s_at, M34079_at, Hs.250758.0.S1_3p_s_at, A_23_P104607, A_23_P104605, CCDS7935, GE61288, M34079, BC008713, BC073165, BC106920, BC107804, AK222485, CR456731, EntrezGene:5702, GI_24430153-S, ILMN_22724, IPI00018398, MIM:186852, AAA36666, AAH08713, AAH73165, AAI06921, AAI07805, BAD96205, CAG33012, NM_002804, NP_002795, Hs.250758, P17980, PRS6A_HUMAN, IPR003960, IPR003959
Reference entity	UniProt:P17980 PSMC3
Cellular compartment	cytosol GO
Organism	Homo sapiens
Component of	26S proteasome [cytosol]
HIV Infection - Host Interactions of HIV factors - Vif-mediated degradation of APOBEC3G - Proteosome-mediated degradation of APOBEC3G [Homo sapiens] - Vpu mediated degradation of CD4 - Degradation of ubiquitinated CD4 [Homo sapiens] Cell Cycle Checkpoints - G1/S DNA Damage Checkpoints - p53-Dependent G1/S DNA damage checkpoint - p53-Dependent G1 DNA Damage Response - Stabilization of p53 - Autodegradation of the E3 ubiquitin ligase COP1 - Proteasome mediated degradation of COP1 [Homo sapiens] - p53-Independent G1/S DNA damage checkpoint - p53-Independent DNA Damage Response - Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - Proteolytic degradation of ubiquitinated-Cdc25A [Homo sapiens] DNA Replication - Mitotic M-M/G1 phases - M/G1 Transition - DNA Replication Pre-Initiation - Assembly of the pre-replicative complex - CDT1 association with the CDC6:ORC:origin complex - Ubiquitinated geminin is degraded by the proteasome [Homo sapiens] - Synthesis of DNA - Switching of origins to a post-replicative state - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] - Regulation of DNA replication - Removal of licensing factors from origins - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] Metabolism of amino acids and derivatives - Regulation of ornithine decarboxylase (ODC) - 26S proteosome degrades ODC holoenzyme complex [Homo sapiens] Regulation of activated PAK-2p34 by proteasome mediated degradation - Proteasome mediated degradation of PAK-2p34 [Homo sapiens] Signaling by Wnt - Degradation of beta-catenin by the destruction complex - Degradation of ubiquitinated -beta catenin by the proteasome [Homo sapiens] Apoptosis - Regulation of Apoptosis - Regulation of activated PAK-2p34 by proteasome mediated degradation - Proteasome mediated degradation of PAK-2p34 [Homo sapiens] Cell Cycle, Mitotic - S Phase - Synthesis of DNA - Switching of origins to a post-replicative state - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] - Ubiquitin-dependent degradation of Cyclin D - Ubiquitin-dependent degradation of Cyclin D1 - Proteasome mediated degradation of Cyclin D1 [Homo sapiens] - Regulation of DNA replication - Removal of licensing factors from origins - Orc1 removal from chromatin - Ubiquitinated Orc1 is degraded by the proteasome [Homo sapiens] - CDK-mediated phosphorylation and removal of Cdc6 - Ubiquitinated Cdc6 is degraded by the proteasome [Homo sapiens] - Mitotic M-M/G1 phases - M/G1 Transition - DNA Replication Pre-Initiation - Assembly of the pre-replicative complex - CDT1 association with the CDC6:ORC:origin complex - Ubiquitinated geminin is degraded by the proteasome [Homo sapiens] - Regulation of mitotic cell cycle - APC/C-mediated degradation of cell cycle proteins - Regulation of APC/C activators between G1/S and early anaphase - SCF-beta-TrCP mediated degradation of Emi1 - SCF-mediated degradation of Emi1 [Homo sapiens] - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins - APC/C:Cdc20 mediated degradation of mitotic proteins - APC/C:Cdc20 mediated degradation of Securin - Degradation of multiubiquitinated Securin [Homo sapiens] - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - Degradation of multiubiquitinated cell cycle proteins [Homo sapiens] - APC/C:Cdh1-mediated degradation of Skp2 [Homo sapiens] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Degradation multiubiquitinated Cyclin A [Homo sapiens]
Other forms of this molecule	26S protease regulatory subunit 6A [nucleoplasm]
Entities deduced on the basis of this entity	ENSCAFP00000012805 [cytosol] E E [Canis familiaris] Q3SZ81 [cytosol] U E E G B C d [Bos taurus] Q1JP95 [cytosol] U E E G B C d [Bos taurus] Homologues of 26S protease regulatory subunit 6A [cytosol] [Bos taurus] O88685 [cytosol] U E E G B C d R H R [Mus musculus] Q63569 [cytosol] U K E E G B C d R H R [Rattus norvegicus] ENSTGUP00000010738 [cytosol] E E [Taeniopygia guttata] Q6DIE6 [cytosol] U K E E [Xenopus tropicalis] Q6IQL5 [cytosol] U K E E G B C d R H R [Danio rerio] Q9XZC3 [cytosol] U E E G B C d F R [Drosophila melanogaster] Q9V3V6 [cytosol] U K E E G B C d F R [Drosophila melanogaster] Homologues of 26S protease regulatory subunit 6A [cytosol] [Drosophila melanogaster] O76371 [cytosol] U K E W E G B C d R H R [Caenorhabditis elegans] Q5SNC0 [cytosol] U K E [Oryza sativa] A3B8V5 [cytosol] U E [Oryza sativa] A2Y9V7 [cytosol] U E [Oryza sativa] Q8W3M9 [cytosol] U E [Oryza sativa] P46465 [cytosol] U K E [Oryza sativa] Homologues of 26S protease regulatory subunit 6A [cytosol] [Oryza sativa] Q54PN7 [cytosol] U E d [Dictyostelium discoideum] Q8II60 [cytosol] U K E P [Plasmodium falciparum]

Click on the map:		shifts focus		zooms in		zooms out