Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) [Homo sapiens]

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Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
Stable identifier	REACT_22166.1
Authored	May, B, 2009-07-04
Reviewed	Chao, JA, 2010-05-30 Singer, RH, 2010-05-30
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Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation, stability, and subcellular localization. IGF2BP1, IGF2BP2, and IGF2BP3 bind about 8400 protein-coding transcripts. The target RNAs contain the sequence motif CAUH (where H is A, U, or, C) and binding of IGFBPs increases the stability of the target RNAs.
Organism	Homo sapiens
Cellular compartment	cytosol GO
Hafner, M, Landthaler, M, Burger, L, Khorshid, M, Hausser, J, Berninger, P, Rothballer, A, Ascano M, Jr, Jungkamp, AC, Munschauer, M, Ulrich, A, Wardle, GS, Dewell, S, Zavolan, M, Tuschl, T Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP 2010 Cell PubMed Yisraeli, JK VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins 2005 Biol Cell PubMed Vikesaa, J, Hansen, TV, Jønson, L, Borup, R, Wewer, UM, Christiansen, J, Nielsen, FC RNA-binding IMPs promote cell adhesion and invadopodia formation 2006 EMBO J PubMed Nielsen, FC, Nielsen, J, Christiansen, J A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking 2001 Scand J Clin Lab Invest Suppl PubMed Oberman, F, Rand, K, Maizels, Y, Rubinstein, AM, Yisraeli, JK VICKZ proteins mediate cell migration via their RNA binding activity 2007 RNA PubMed Nielsen, J, Christiansen, J, Lykke-Andersen, J, Johnsen, AH, Wewer, UM, Nielsen, FC A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development 1999 Mol Cell Biol PubMed
Participating molecules
Beta-actin mRNA isoform 001 [cytosol] E CD44 mRNA isoform 201 [cytosol] E CD44 mRNA isoform 202 [cytosol] E CD44 mRNA isoform 203 [cytosol] E CD44 mRNA isoform 204 [cytosol] E CD44 mRNA isoform 205 [cytosol] E H19 noncoding RNA [cytosol] E Insulin-like growth factor 2 mRNA-binding protein 1 [cytosol] U E G B C d R H U R Insulin-like growth factor 2 mRNA-binding protein 2 [cytosol] U K E G B C d O R H U R P Insulin-like growth factor 2 mRNA-binding protein 3 [cytosol] U K E G B C d O R H U R ... List all 16 participating molecules

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