Energy dependent regulation of mTOR by LKB1-AMPK

Energy dependent regulation of mTOR by LKB1-AMPK [Homo sapiens]

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Energy dependent regulation of mTOR by LKB1-AMPK
DOI	10.3180/REACT_21387.1
Stable identifier	REACT_21387.1
Authored	Katajisto, P, Makela, T, Wu, J, 2008-11-19
Reviewed	Zheng, B, 2009-10-20
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Upon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. If the AMP:ATP ratio rises, this activation is maintained and AMPK activates the TSC complex by phosphorylating TSC2. Active TSC activates the intrinsic GTPase activity of Rheb, resulting in GDP-loaded Rheb and inhibition of mTOR pathway.
Organism	Homo sapiens
Guertin, DA, Sabatini, DM Defining the role of mTOR in cancer 2007 Cancer Cell PubMed Hardie, DG AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy 2007 Nat Rev Mol Cell Biol PubMed Katajisto, P, Vallenius, T, Vaahtomeri, K, Ekman, N, Udd, L, Tiainen, M, Mäkelä, TP The LKB1 tumor suppressor kinase in human disease 2007 Biochim Biophys Acta PubMed
Represents GO biological process	cell cycle arrest GO
Equivalent event(s) in other organism(s)	Energy dependent regulation of mTOR by LKB1-AMPK [Canis familiaris] Energy dependent regulation of mTOR by LKB1-AMPK [Bos taurus] Energy dependent regulation of mTOR by LKB1-AMPK [Sus scrofa] Energy dependent regulation of mTOR by LKB1-AMPK [Mus musculus] Energy dependent regulation of mTOR by LKB1-AMPK [Rattus norvegicus] Energy dependent regulation of mTOR by LKB1-AMPK [Gallus gallus] Energy dependent regulation of mTOR by LKB1-AMPK [Taeniopygia guttata] Energy dependent regulation of mTOR by LKB1-AMPK [Xenopus tropicalis] Energy dependent regulation of mTOR by LKB1-AMPK [Danio rerio] Energy dependent regulation of mTOR by LKB1-AMPK [Drosophila melanogaster] Energy dependent regulation of mTOR by LKB1-AMPK [Caenorhabditis elegans] Energy dependent regulation of mTOR by LKB1-AMPK [Arabidopsis thaliana] Energy dependent regulation of mTOR by LKB1-AMPK [Oryza sativa] Energy dependent regulation of mTOR by LKB1-AMPK [Dictyostelium discoideum] Energy dependent regulation of mTOR by LKB1-AMPK [Saccharomyces cerevisiae] Energy dependent regulation of mTOR by LKB1-AMPK [Schizosaccharomyces pombe]
Participating molecules
ADP [cytosol] C C P AMP [cytosol] C C P AMPK alpha [cytosol] AMPK alpha1 [cytosol] U K E G B C d O R H U R AMPK alpha2 (inactive) [cytosol] U K E G B C d O R H U R AMPK beta [cytosol] AMPK beta1 [cytosol] U K E G B C d O R H U R AMPK beta2 [cytosol] U K E G B C d O R H U R P AMPK gamma [cytosol] AMPK gamma1 [cytosol] U K E G B C d O R R H H U R R ... List all 34 participating molecules

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